The pathogenesis of the hemorrhagic state in radiation sickness: a review.

T HE Ii\’IPORTANCE OF HEMORRHAGE as a part of the acute radiations syndrome is well recogisized. Warrets’ atsd LeRoy2 cite bleeding as a major cause of death iti radiation sickmsess atnomig the Japanese exposed to atonsic bomb radiations. The frequenscy of hemorrhagic nianifestations has heens emphasized! Isy Cromikite.3 Although bleeding is a more or less coisstaist feature of the acute radiation synndromsse, its presemsce and degree are depemsdeist ott species differensces, dose, amid timsse.4’ The imifluence of these factors has oftens beets overlooked, as a result of which comsfusions exists ins the literature. Henssorrhage is msiore widespread amid severe its man, the dog, aisd the guitsea pig thats in the mouse, rat, or rabbit.5 The early clinical amsd experimental reports have beets cited elsewhere.5 ‘ 6 , 7 In the presenst review eniphasis will be placed ons recent studies of the pathogensesis of radiations-induced hemorrhage.